莫匹羅星MupirocinMelting Point: 77–78°C
Boiling Point: 672°C
Specific Rotation: D20 -19.3° (c = 1 in methanol)
Density: 1.183 ± 0.06 g/cm3 (Predicted)
Flash Point: >110°C (230°F)
Storage Conditions: Inert atmosphere, store in freezer below -20°C
Solubility: Solubility in water 12 mg/mL
Appearance: Solid
Acidity Constant (pKa): 4.78 ± 0.10 (Predicted)
Color: White to brownish
Optical Rotation: [α]/D -15.7 to -20°, c = 1 in methanol
Water Solubility: Soluble in DMSO or methanol. Sparingly soluble in water
Maximum Wavelength (λmax): 222 nm (EtOH) (lit.)
Merck: 14,6302
Stability: Stable for up to 1 month in DMSO solution stored at -20°C
InChIKey: MINDHVHHQZYEEK-HBBNESRFSA-N
CAS Database: 12650-69-0 (CAS DataBase Reference)
Introduction:
Mupirocin, also known as pseudomonic acid A, is a relatively ideal topical antibacterial agent. It was launched in 1985 by GlaxoSmithKline under the brand name “Bactroban.” The U.S. FDA approved its use in the United States in 1987, and China approved its production and sale by Sino-American GlaxoSmithKline in 1993. Mupirocin is mainly used for the prevention and treatment of skin bacterial infections caused by Gram-positive cocci.
Indications:
Mupirocin is primarily used for the prevention and treatment of skin bacterial infections caused by Gram-positive cocci, such as impetigo, furuncles, folliculitis (primary skin infections), and secondary skin infections including eczema with infection, ulcers with infection, and wounds with infection. The main antibacterial mechanism of mupirocin is to inhibit bacterial protein synthesis.
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